Brief ReportThe breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue
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Abbreviations
BAT
Brown adipose tissue
βHB
β-HydroxyButyrate
KLB
βKlotho
DIO
Diet induced obese
EGR1
Early growth response protein 1
FGF19
Fibroblast growth factor 19
FGF21
Fibroblast growth factor 21
FGFR
Fibroblast growth factor receptor
FFA
Free fatty acids
ACADL
Long chain acetyl-CoA dehydrogenase
PGC1α
PPARγ coactivator 1α
SCD1
Stearoyl-Coenzyme A desaturase 1
TG
Triglycerides
WAT
White adipose tissue
UCP1
Uncoupling protein 1
ACADVL
Very long chain acetyl-CoA dehydrogenase.
Keywords
FGF21
Adipose tissue
FGFR1
FGF19
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A.C.A. and C.Y. contributed equally to this work.
Copyright © 2012 Elsevier GmbH.