Original articleTissue-selective estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice
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Abbreviations
Akt
protein kinase B
AMPKα
AMP-activated protein kinase α
AUC
area-under the curve
BAT
brown adipose tissue
BZA
bazedoxifene
CE
conjugated equine estrogens
E2
17β-estradiol
ER
estrogen receptor
FAS
fatty acid synthase
FGF21
fibroblast growth factor 21
GIR
glucose infusion rate
H&E
hematoxylin and eosin
HFD
high-fat diet
HGP
hepatic glucose production
ITT
insulin tolerance test
Lcn2
lipocalin 2
LPL
lipoprotein lipase
NAFLD
non-alcoholic fatty liver disease
OGTT
oral glucose tolerance test
OVX
ovariectomy
PTT
pyruvate tolerance test
RBP4
retinol binding protein 4
Rd
rate of whole-body glucose disappearance
RER
respiratory exchange ratio
SERM
selective estrogen receptor modulator
TBARS
thiobarbituric acid reactive substances
TG
triacylglycerol
TSEC
tissue-selective estrogen complex
UCPs
uncoupling proteins
VO2
oxygen consumption
WAT
white adipose tissue.
Keywords
Tissue-selective estrogen complexes
Bazedoxifene
Menopause
Metabolic syndrome
Insulin resistance
Type 2 diabetes
Cited by (0)
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Present address: Department of Food and Biotechnology, Korea University, Sejong 339-700, South Korea
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Present address: CNRS, UMR6265, INRA, UMR1324, University of Bourgogne, CSGA, F-21000 Dijon, France
Copyright © 2014 The Authors. Published by Elsevier GmbH