Original articleMunc18c mediates exocytosis of pre-docked and newcomer insulin granules underlying biphasic glucose stimulated insulin secretion in human pancreatic beta-cells
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Keywords
Munc18c
Exocytosis
Newcomer insulin granules
Human islets
Abbreviations
Syn
syntaxin
SG
secretory insulin-containing granule
GSIS
glucose-stimulated insulin secretion
PM
plasma membrane
KD
knock down
CmPatch
clamp capacitance measurements
TIRFM
total internal reflection fluorescence microscopy
RRP
readily releasable pool
SNARE
soluble N-ethylmaleimide-sensitive factor attachment protein receptor
SM
Sec1/Munc18-like protein
v-
vesicle-
t-
target-
VAMPs
Vesicle Associated Membrane Proteins
SNAP25/23
synaptosomal-associated protein of 25/23 kD
GLP-1
glucagon-like peptide-1
T2DM
type 2 diabetes mellitus
Ad
adenovirus
EGFP
enhanced green fluorescent protein
NPY
neuropeptide Y
Cited by (0)
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Dan Zhu and Li Xie are equal contributors.
Copyright © 2015 The Authors. Published by Elsevier GmbH