Original articleTNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway
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Keywords
IP6K
Inositol pyrophosphate
Obesity
Energy expenditure
Diabetes
Akt
Abbreviations
IP6K
Inositol hexakisphosphate kinase
5-IP7
diphosphoinositol pentakisphosphate
TNP
[N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine]
CD
chow-diet
HFD
high-fat diet
DIO
diet-induced obesity
T2D
type-2 diabetes
EE
energy expenditure
H&E
hematoxylin and eosin
AUC
area under curve
WAT
white adipose tissue
EWAT
epididymal adipose tissue
IWAT
inguinal adipose tissue
RWAT
retroperitoneal adipose tissue
BAT
brown adipose tissue
Q-NMR
quantitative nuclear magnetic resonance
HPLC
high performance liquid chromatography
PCR
polymerase chain reaction
QRT-PCR
quantitative reverse transcription polymerase chain reaction
GTT
glucose tolerance test
ITT
insulin tolerance test
T308
threonine 308
S473
serine 473
S9
serine 9
VO2
volume of oxygen consumption
RER
Respiratory exchange ratio
ALT
alanine aminotransferase
AST
aspartate transaminase
IP6K1-KO
IP6K1 knockout
GSK3
glycogen synthase kinase
PKA
protein kinase A
UCP-1/3
uncoupling protein 1/3
Cidea
cell death activator-A
PPARγ
peroxisome proliferator-activated receptor gamma
PGC1α
PPAR coactivator 1 alpha
PRDM16
PR domain containing 16
CPT1a
carnitine palmitoyltransferase I
SREV-TNP
short-term TNP treatment for reversal of DIO
Pro-TNP
TNP treatment for protection against DIO
Rev-TNP
long-term TNP treatment for reversal of DIO
RevT-TNP
Long-term TNP treatment for reversal of DIO at thermoneutral temperature
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Current address: Department of Chemistry, University of Cambridge, UK.
Copyright © 2016 The Author(s). Published by Elsevier GmbH