Elsevier

Molecular Metabolism

Volume 6, Issue 3, March 2017, Pages 276-287
Molecular Metabolism

Brief Communication
Divergent effects of a designer natriuretic peptide CD-NP in the regulation of adipose tissue and metabolism

https://doi.org/10.1016/j.molmet.2016.12.010Get rights and content
Under a Creative Commons license
open access

Highlights

  • The optimized designer natriuretic peptide CD-NP promotes adipogenesis.

  • Duration of treatment is decisive: short-term promotes browning whereas long-term treatment exacerbates obesity and diabetes.

  • Long-term CD-NP treatment reduces WAT inflammation and increases adiponectin expression.

Abstract

Objective

Obesity is defined as an abnormal increase in white adipose tissue (WAT) and is a major risk factor for type 2 diabetes and cardiovascular disease. Brown adipose tissue (BAT) dissipates energy and correlates with leanness. Natriuretic peptides have been shown to be beneficial for brown adipocyte differentiation and browning of WAT.

Methods

Here, we investigated the effects of an optimized designer natriuretic peptide (CD-NP) on murine adipose tissues in vitro and in vivo.

Results

In murine brown and white adipocytes, CD-NP activated cGMP production, promoted adipogenesis, and increased thermogenic markers. Consequently, mice treated for 10 days with CD-NP exhibited increased “browning” of WAT. To study CD-NP effects on diet-induced obesity (DIO), we delivered CD-NP for 12 weeks. Although CD-NP reduced inflammation in WAT, CD-NP treated DIO mice exhibited a significant increase in body mass, worsened glucose tolerance, and hepatic steatosis. Long-term CD-NP treatment resulted in an increased expression of the NP scavenging receptor (NPR-C) and decreased lipolytic activity.

Conclusions

NP effects differed depending on the duration of treatment raising questions about the rational of natriuretic peptide treatment in obese patients.

Keywords

Natriuretic peptides
cGMP
Adipocytes
Browning
Diet-induced obesity

Cited by (0)