ReviewEndoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells
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Keywords
Diabetes
Endoplasmic reticulum stress
eIF2α
Pancreatic β cell
Insulin
Islet
Abbreviations
ATF
activating transcription factor
CHOP
C/EBP homologous protein
CReP
constitutive repressor of eIF2α phosphorylation
CRISPR
clustered regularly interspaced short palindromic repeats
eIF2
eukaryotic translation initiation factor 2
ER
endoplasmic reticulum
ERAD
ER-associated degradation
GCN2
general control non-derepressible-2
GIP
glucose-dependent insulinotropic polypeptide
GLP-1
glucagon-like peptide 1
GWAS
genome-wide association study
hESC
human embryonic stem cell
hiPSC
human induced pluripotent stem cell
HNF1A
hepatocyte nuclear factor 1-α
hPSC
human pluripotent stem cell
HRI
heme-regulated inhibitor kinase
IAPP
islet amyloid polypeptide
IER3IP1
immediate early response-3 interacting protein-1
IRE1
inositol-requiring protein-1
ISR
integrated stress response
MEHMO
mental retardation, epilepsy, hypogonadism and -genitalism, microcephaly and obesity
MODY
maturity-onset diabetes of the young
NRF2
nuclear factor, erythroid 2 like 2
PBA
4-phenyl butyric acid
Pdx1
pancreatic duodenal homeobox 1
PERK
PKR-like ER kinase
PKR
protein kinase RNA
PP1
protein phosphatase 1
PPA
phenylpropenoic acid glucoside
RIDD
regulated IRE1-dependent decay
RyR2
type 2 ryanodine receptor/Ca2+ release channel
SERCA
sarcoendoplasmic reticulum Ca2+ ATPase
TUDCA
taurine-conjugated ursodeoxycholic acid derivative
uORF
upstream open reading frame
UPR
unfolded protein response
WFS
Wolfram syndrome
XBP1
X-box binding protein 1
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© 2017 The Authors. Published by Elsevier GmbH.