Original ArticleFibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury
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open access
Keywords
Binge ethanol consumption
FGF21
Chronic ethanol consumption
Alcoholic liver disease
Abbreviations
ACSS2
acyl-coenzyme a synthetase short-chain family member 2
ADH 1 and 2
alcohol dehydrogenase 1 and 2
ALDH1α1
aldehyde dehydrogenase 1 alpha 1
ALD
alcoholic liver disease
ALT
alanine aminotransferase
CD68
cluster of differentiation 68
ChREBPβ
carbohydrate-responsive element-binding protein beta
CPT1α
carnitine palmitoyltransferase 1 alpha
CPT1β
carnitine palmitoyltransferase 1 beta
CYP2E1
cytochrome P450 family 2 subfamily E member 1
FAS
fatty acid synthase
FGF21
fibroblast growth factor 21
FGF21-KO
mice lacking the FGF21 gene
FGF21-OE
mice overexpressing the FGF21 gene
IP
intraperitoneal
LDC
Lieber–DeCarli diet
MCP1
monocyte chemoattractant protein 1
NAFLD
non-alcoholic fatty liver disease
PPARα
peroxisome proliferator-activated receptor alpha
SC
subcutaneous
SCD1
stearoyl-CoA desaturase 1
SEM
standard error of the mean
SREBP1c
sterol regulatory element-binding protein-1c
TNFα
tumor necrosis factor alpha
UCP2
uncoupling protein 2
WT
wild type
Cited by (0)
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Present address: Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, 00161 Rome, Italy.
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Present address: 1Globe Health Institute, Norwood MA 02062, USA.
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Present address: Alkermes Inc., Waltham MA 02451, USA.
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Equally contributing authors.
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Equally contributing senior authors.
© 2017 The Authors. Published by Elsevier GmbH.