Original ArticlePharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis
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open access
Keywords
Obesity
Lipid metabolism
Inflammation
Abbreviations
AAV8
adeno-associated virus serotype 8
Abcd1
ATP binding cassette subfamily D member 1
Acadl
acyl-CoA deshydrogenase, long-chain
Acadm
acyl-CoA deshydrogenase, medium chain
ACC
acetyl-CoA carboxylase
Acox
acyl-CoA oxidase 1
Ad
adenovirus
ALT
alanine aminotransferase
ApoB
apolipoprotein b
ASM
acid-soluble metabolites
AST
aspartate aminotransferase
AUC
area under curve
BSA
bovine serum albumin
CDHFD
choline-deficient high fat diet
CHOP
C/EBP-homologous protein
DG
diacylglycerol
DIO
diet-induced obesity
DN
dominant negative
DOX
Doxorubicin
EC
sterified cholesterol
ER stress
endoplasmic reticulum stress
FAS
fatty acid synthase
Fatp2
solute carrier family 27 (fatty acid transporter) member 2
FA
free fatty acid
GAPDH
glyceraldehyde-3-phosphate deshydrogenase
GFP
green fluorescent protein
GTT
glucose test tolerance
HFD
high fat diet
i.p.
intraperitoneal
IL10
interleukin 10
IL1β
interleukin 1beta
IL6
initerleukin 6
ITT
insulin test tolerance
JNK
c-Jun N-terminal kinase
MCD
methionine-choline deficient diet
NAFLD
non-alcoholic fatty liver disease
NASH
non-alcoholic steatohepatitis
NFκβ
nuclear factor kappa b
OA
oleic acid
pACC
phospho acetyl-CoA carboxylase
pIRE
Inositol-requiring enzyme 1 α
pJNK
phospho c-Jun N-terminal kinase
Pparα
peroxisome proliferator activated receptor alpha
Quer
quercetin
SPF
specific pathogen free room
TG
triglyceride
TNFα
tumor necrosis factor alpha
UPR
unfolded protein response
XBP1s
X-box binding protein 1
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Copyright © 2017 The Authors. Published by Elsevier GmbH