Original ArticleAntiretroviral therapy potentiates high-fat diet induced obesity and glucose intolerance
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Graphical abstract
Keywords
Antiretroviral therapy
Obesity
Glucose intolerance
Adipose tissue inflammation
Insulin resistance
Macrophage activation
Abbreviations
AIDS
acquired immunodeficiency syndrome
ART
antiretroviral therapy
ATM
adipose tissue macrophage
DIO
diet-induced obesity
eWAT
epididymal white adipose tissue
GTT
glucose tolerance test
SD
standard chow diet
HFD
high fat diet
HIV
human immunodeficiency virus
HOMA-IR
homeostatic model assessment of insulin resistance
ITT
insulin tolerance test
NAFLD
non-alcoholic fatty liver disease
NO
nitric oxide
NRTIs
nucleoside reverse-transcriptase inhibitors
PTK
protein tyrosine kinase
ROS
reactive oxygen species
STK
serine/threonine kinase
T2D
type-2 diabetes
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© 2018 The Authors. Published by Elsevier GmbH.